Treatment of chronic wounds

OZONE TREATMENT

Ozone has already been presented many times, in brief it shows the effects:
• antibacterial (most chronic wounds, despite the use of antibiotic therapy, are not sterile, which contributes to poor healing)
• anti-inflammatory and analgesic
• supporting granulation (tissue healing)
• increasing the antioxidant capacity of plasma (the existence of a chronic wound indirectly increases the amount of free radicals in the body)
• oxygenating organism (only tissues properly supplied with blood and oxygenated can regenerate properly)
In Spanish oncology centers, the ozonotherapy method is also used in patients with non- healing wounds / burns after radiation therapy, observing much faster wound healing.

As shown by studies by Zhang et al. Published in 2014 in “Oxidative Medicine and Cellular Longevity”, under the influence of ozone therapy in patients with diabetic foot increases the level of growth factors: VEGF, TGF beta and PDGF. It is a mechanism by which the first stage of wound healing is stimulated – the formation of new vessels. In the second stage, TGF beta manages further wound healing at the cellular level.

Another mechanism that underlies the acceleration of wound healing is the improvement of the proliferation of keratinocytes and cells of the basal layer of the skin (details below in the section “for doctors”).

MILTA PHOTOTHERAPY

The emitted light photons of the appropriate wavelength, “set” in a magnetic tunnel, stimulate cell renewal processes, contributing to tissue regeneration, and in this case wound healing. In addition, the anti-inflammatory effect, and thus analgesic and anti-edema, improves the quality of life and facilitates normal functioning.
What’s more, in the MILTA protocol we do not only “expose” the wound. We start by improving the blood supply to the whole body, supporting detoxification of liver function and supporting bowel function. This is truly holistic therapy and we see its exceptional effectiveness in it.
Technical details: MILTA photostimulation technology combines laser transmitters (so-called soft lasers), infrared diodes (IR) and visible light diodes: red, green and blue in a magnetic tunnel. The combination of the wavelengths used so far in other therapies allows to work at a much greater depth, inaccessible to conventional LEDs – even up to 13 cm in soft tissues.

SUPPLEMENTATION OF PROCOLLAGEN AMINO ACIDS AND VITAMIN C

We know the truth “you can’t get honey from the rock”…
For the body to have a chance for faster recovery, it must be properly nourished, in addition sometimes the need for collagen supplementation (collagen broths, jellies, oral supplementation) or its components (amino acids such as lysine or proline may also be administered intravenously). Collagen needs to be crosslinked for proper incorporation. This happens with the help of vitamin C. In the case of chronic diseases and their complications we are talking about here, i.e. chronic non-healing wounds, the demand for vitamin C is very high. There is sometimes talk of tissue scurvy that can be remedied by intravenous vitamin C administration.
However, vitamin C has other synergistic effects. It is the best known antioxidant, has antihistamine capabilities, supporting the immune system and many others.
The above-mentioned therapies are successfully used at the Salus Institute of Ozonotherapy. Complementary Medicine. We invite you to a consultation during which you will be able to ask all your questions.

For doctors:

As a result of the analysis of available clinical studies, it was concluded that ozone therapy may provide shorter healing time of chronic wounds in comparison with other methods of treatment . (1)
In vitro studies provide answers as to the mechanism of action of ozone in the process of stimulating wound healing. Activation of AMP kinase comes to the fore . It is the same pathway that is responsible for the anti-inflammatory and analgesic effects of ozone. (2)
Xiaoqi Wang has shown that levels of growth factors such as EGF and IGF-1 are lowered in diabetic patients. It turns out that at high glycemic levels, to improve cell proliferation and migration (keratinocytes), it is necessary to stimulate both receptors, both EGFR and IGF1R. Topical application of ozone has been shown to play such a role , increases the level of both growth factors locally and increases the proliferation of keratinocytes and skin basal layer cells.
Our team’s observations are even more extensive. In Polish realities, in which ozonotherapy is present as free treatment only in a few centers conducting scientific research (3) (the costs of procedures are covered by scientific grants), as is the case e.g. in wound treatment centers (Burn Treatment Center in Siemianowice Śląskie) ozone therapy still remains a niche therapeutic method. This is not altered by the fact that ozone therapy already finds its place in the guidelines for treating diabetic foot.
1. Fitzpatrick E, Holland OJ, Vanderlelie JJ. Ozone therapy for the treatment of chronic wounds: A systematic review. Int Wound J. 2018 Aug; 15 (4): 633-644. doi:
10.1111 / iwj.12907. Epub 2018 Mar 13. PubMed PMID: 29536625.
2. Wen-Tao Liu “Translational medicine research of medical ozone via AMPK activation in anti-inflamatory, alalgesic and promoting wound healing” Canton Interventional Forum 09.11.2018
3. In the 1990s, the Silesian Health Fund reimbursed ozone therapy.